Issue 31, 2019
From the journal:

Chemical Communications

Synthetic and immunological studies of Salmonella Enteritidis O-antigen tetrasaccharides as potential anti-Salmonella vaccines†

Chang-Xin Huo,‡a   Debashis Dhara,‡b   Scott M. Baliban,c   Setare Tahmasebi Nick,a   Zibin Tan,a   Raphael Simon,*c   Anup Kumar Misra ORCID logo *b  and  Xuefei Huang ORCID logo *a  

* Corresponding authors

a Departments of Chemistry and Biomedical Engineering, Institute for Quantitative Health Science & Engineering, Michigan State University, 578 South Shaw Lane, East Lansing, MI 48824, USA
E-mail: xuefei@chemistry.msu.edu

b Division of Molecular Medicine, Bose Institute, P-1/12, C.I.T. Scheme VII M, Kolkata 700054, India
E-mail: anup@jcbose.ac.in

c Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA
E-mail: rsimon@som.umaryland.edu

Abstract

The first synthetic carbohydrate based potential anti-Salmonella Enteritidis vaccine has been developed by conjugating a synthetic tetrasaccharide antigen with bacteriophage Qβ. High levels of specific and long lasting anti-glycan IgG antibodies were induced by the conjugate, which completely protected mice from lethal bacterial challenges in a passive transfer model.

Graphical abstract: Synthetic and immunological studies of Salmonella Enteritidis O-antigen tetrasaccharides as potential anti-Salmonella vaccines

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Article information

DOI
https://doi.org/10.1039/C8CC08622B
Article type
Communication
Submitted
28 Oct 2018
Accepted
11 Mar 2019
First published
19 Mar 2019

Chem. Commun., 2019,55, 4519-4522

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Synthetic and immunological studies of Salmonella Enteritidis O-antigen tetrasaccharides as potential anti-Salmonella vaccines

C. Huo, D. Dhara, S. M. Baliban, S. Tahmasebi Nick, Z. Tan, R. Simon, A. K. Misra and X. Huang, Chem. Commun., 2019, 55, 4519 DOI: 10.1039/C8CC08622B

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