Issue 7, 2019
From the journal:

Chemical Communications

MRI micelles self-assembled from synthetic gadolinium-based nano building blocks†

Andrej Babič, ORCID logo *a   Vassily Vorobiev,a   Gregor Trefalt, ORCID logo b   Lindsey A. Crowe,c   Lothar Helm, ORCID logo d   Jean-Paul Valléec  and  Eric Allémann ORCID logo a  

* Corresponding authors

a Pharmaceutical Technology, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 1211 Geneva 4, Switzerland
E-mail: andrej.babic@unige.ch

b Department of Inorganic and Analytical Chemistry, University of Geneva, 1205 Geneva 4, Switzerland

c Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, 1211 Geneva 4, Switzerland

d Institut des Sciences et Ingénierie Chimiques, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland

Abstract

A synthetic nano building block endowed with amphiphilic properties and chelated gadolinium is presented. Spontaneous self-assembly into small 12 nm corona-core stealth Gd-micelles with inherently high gadolinium loading occurs in water. Gd-Micelles are a new blood pool contrast agent with high relaxivity for magnetic resonance imaging.

Graphical abstract: MRI micelles self-assembled from synthetic gadolinium-based nano building blocks

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Article information

DOI
https://doi.org/10.1039/C8CC08875F
Article type
Communication
Submitted
07 Nov 2018
Accepted
14 Dec 2018
First published
18 Dec 2018

Chem. Commun., 2019,55, 945-948

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MRI micelles self-assembled from synthetic gadolinium-based nano building blocks

A. Babič, V. Vorobiev, G. Trefalt, L. A. Crowe, L. Helm, J. Vallée and E. Allémann, Chem. Commun., 2019, 55, 945 DOI: 10.1039/C8CC08875F

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