New half-sandwich ruthenium(ii) complexes as proteosynthesis inhibitors in cancer cells

Abstract

Half-sandwich ruthenium(II) complexes [(η⁶-p-cymene)Ru(C^N)-(X)]^0/+ (X = Cl, py or 4-NMe₂-py) containing a cyclometalated 2-ppy or 1-ppz with a non-coordinated CHO group as a handle for further functionalization have been synthesized to achieve selective cytotoxicity to cancer cells, the more potent compounds acting as proteosynthesis inhibitors; this is a new mode of action for half-sandwich metal complexes.