Homogenous deposition of matrix–analyte cocrystals on gold-nanobowl arrays for improving MALDI-MS signal reproducibility†
Abstract
The non-uniform deposition of matrix–analyte cocrystals and poor ionization are major obstacles in quantitative analysis through MALDI-MS. An Au-nanobowl array was prepared and applied to overcome these limitations, which enabled the quantitative detection of oligonucleotides and polypeptides.