Half-curcumin analogues as PET imaging probes for amyloid beta species

Jian Yang; Ran Cheng; Hualong Fu; Jing Yang; Mohanraja Kumar; Jie Lu; Yungen Xu; Steven H. Liang; Mengchao Cui; Chongzhao Ran

doi:10.1039/C8CC10166C

Half-curcumin analogues as PET imaging probes for amyloid beta species†

Jian Yang,‡^ab Ran Cheng,‡^c Hualong Fu,^d Jing Yang,^ae Mohanraja Kumar,^f Jie Lu,^g Yungen Xu,^b Steven H. Liang,

^c Mengchao Cui

*^d and Chongzhao Ran

*^a

Author affiliations

* Corresponding authors

^a Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
E-mail: cran@nmr.mgh.harvard.edu

^b School of Pharmacy, Pharmaceutical University, Nanjing, China

^c Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, Boston, MA, USA

^d Key Laboratory of Radiopharmaceuticals, College of Chemistry, Beijing Normal University, Beijing 100875, China
E-mail: cmc@bnu.edu.cn

^e School of Pharmacy, Soochow University, Suzhou, China

^f Department of Chemistry, Massachusetts Institute of Technology, USA

^g XuanWu Hospital, Capital Medical University, Beijing, China

Abstract

In this report, we demonstrate that half-curcuminoid could be a better scaffold for PET tracer development. F-CRANAD-101 was designed and found to show significant response to both soluble and insoluble Aβs in the fluorescent spectral tests. PET imaging results indicated that 14 month and 5 month old APP/PS1 AD mice had higher signals in the brain than age-matched wild type mice.

Chemical Communications

Half-curcumin analogues as PET imaging probes for amyloid beta species†

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Half-curcumin analogues as PET imaging probes for amyloid beta species

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