Co-assembled supramolecular hydrogels of doxorubicin and indomethacin-derived peptide conjugates for synergistic inhibition of cancer cell growth

Abstract

Conjugation of indomethacin with a self-assembling peptide moiety affords co-assembled supramolecular nanostructures of doxorubicin and peptide derivatives for tunable release of two drugs and synergistic effects against cancer cells, which illustrates a simple and effective approach to utilize co-assembled nanostructures for co-delivery of self-complementary drug pairs.