C–H 18F-fluorination of 8-methylquinolines with Ag[18F]F†
So Jeong
Lee, 
a
Allen F.
Brooks,
a
Katarina J.
Makaravage,
b
Andrew V.
Mossine,
a
Melanie S.
Sanford
*b
and
Peter J. H.
Scott
*a
a
Allen F.
Brooks,
a
Katarina J.
Makaravage,
b
Andrew V.
Mossine,
a
Melanie S.
Sanford
*b
and
Peter J. H.
Scott
*a
Abstract
This report describes a Pd-mediated C–H radiofluorination of 8-methylquinoline derivatives with no-carrier-added Ag[18F]F. To achieve this transformation, a new method was developed for the generation of Ag[18F]F using a sep-pak cartridge. The C–H radiofluorination was then optimized and applied to a series of substituted 8-methylquinoline derivatives. Finally, this method was fully automated using a radiochemistry synthesis module.
![Graphical abstract: C–H 18F-fluorination of 8-methylquinolines with Ag[18F]F](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C9CC00641A&imageInfo.ImageIdentifier.Year=2019)
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