Issue 26, 2019
From the journal:

Chemical Communications

An organoruthenium complex overcomes ABCG2-mediated multidrug resistance via multiple mechanisms†

Leli Zeng,‡ab   Jia Li,‡a   Chen Zhang,a   Yun-Kai Zhang,b   Wei Zhang,bc   Juanjuan Huang,a   Charles R. Ashby, Jr,b   Zhe-Sheng Chen ORCID logo *b  and  Hui Chao ORCID logo *a  

* Corresponding authors

a MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China
E-mail: ceschh@mail.sysu.edu.cn

b College of Pharmacy and Health Sciences, St. John's University, New York, NY 11439, USA
E-mail: chenz@stjohns.edu

c Institute of Plastic Surgery, Weifang Medical University, Weifang, Shandong 261041, P. R. China

Abstract

Multidrug resistance mediated by the overexpression of ABC transporters is a major challenge in cancer chemotherapy. Here, we report the synthesis of an organoruthenium complex, RuF, that was designed to surmount multidrug resistance by combining ABCG2 inhibition and cancer cell cytotoxicity, yielding synergistic efficacy.

Graphical abstract: An organoruthenium complex overcomes ABCG2-mediated multidrug resistance via multiple mechanisms

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Article information

DOI
https://doi.org/10.1039/C9CC00882A
Article type
Communication
Submitted
31 Jan 2019
Accepted
06 Mar 2019
First published
06 Mar 2019

Chem. Commun., 2019,55, 3833-3836

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An organoruthenium complex overcomes ABCG2-mediated multidrug resistance via multiple mechanisms

L. Zeng, J. Li, C. Zhang, Y. Zhang, W. Zhang, J. Huang, C. R. Ashby, Z. Chen and H. Chao, Chem. Commun., 2019, 55, 3833 DOI: 10.1039/C9CC00882A

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