Issue 45, 2019
From the journal:

Chemical Communications

A consecutive process for C–C and C–N bond formation with high enantio-and diastereo-control: direct reductive amination of chiral ketones using hydrogenation catalysts†

Sophie H. Gilbert, ORCID logo a   Virginie Viseura  and  Matthew L. Clarke ORCID logo *a  

* Corresponding authors

a School of Chemistry, University of St Andrews, EaStCHEM, St Andrews, Fife, UK
E-mail: mc28@st-andrews.ac.uk
Fax: +44 (0)1334 463808
Tel: +44 (0)1334 463850

Abstract

High diastereoselectivity was observed in the Rh-catalysed reductive amination of 3-arylcyclohexanones to form tertiary amines. This was incorporated into a one-pot enantioselective conjugate addition and diastereoselective reductive amination, including an example of assisted tandem catalysis.

Graphical abstract: A consecutive process for C–C and C–N bond formation with high enantio-and diastereo-control: direct reductive amination of chiral ketones using hydrogenation catalysts

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C9CC00923J
Article type
Communication
Submitted
31 Jan 2019
Accepted
07 May 2019
First published
10 May 2019

Chem. Commun., 2019,55, 6409-6412

Permissions

Request permissions

A consecutive process for C–C and C–N bond formation with high enantio-and diastereo-control: direct reductive amination of chiral ketones using hydrogenation catalysts

S. H. Gilbert, V. Viseur and M. L. Clarke, Chem. Commun., 2019, 55, 6409 DOI: 10.1039/C9CC00923J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements