Issue 35, 2019
From the journal:

Chemical Communications

Ratiometric fluorescent probes for selective and sensitive visualization of bacterial microenvironment protease activity†

Qinghua Wang,a   Xiang Wang,a   Ying Sun,a   Xiaoxiao Yang,ab   Leilei Zhang,a   Qingyang Zhang, ORCID logo a   Zhi-Qiang Hu ORCID logo c  and  Hai-Yu Hu ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
E-mail: haiyu.hu@imm.ac.cn

b Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia 30303, USA

c College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, China

Abstract

The extracellular SspA protease of the human pathogen S. aureus is essential for evading the host immune defence system. Two novel FRET probes for selective real-time ratiometric imaging of SspA activity in live S. aureus cells are reported.

Graphical abstract: Ratiometric fluorescent probes for selective and sensitive visualization of bacterial microenvironment protease activity

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Article information

DOI
https://doi.org/10.1039/C9CC00953A
Article type
Communication
Submitted
01 Feb 2019
Accepted
11 Mar 2019
First published
12 Mar 2019

Chem. Commun., 2019,55, 5064-5067

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Ratiometric fluorescent probes for selective and sensitive visualization of bacterial microenvironment protease activity

Q. Wang, X. Wang, Y. Sun, X. Yang, L. Zhang, Q. Zhang, Z. Hu and H. Hu, Chem. Commun., 2019, 55, 5064 DOI: 10.1039/C9CC00953A

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