Issue 27, 2019
From the journal:

Chemical Communications

Pd(ii)-Catalyzed decarboxylative meta-C–H difluoromethylation†

Huaxin Zhao,‡a   Guobin Ma,‡b   Xiaojuan Xie,a   Yong Wang,a   Jian Hao*a  and  Wen Wan ORCID logo *ac  

* Corresponding authors

a Department of Chemistry, Shanghai University, Shanghai, China
E-mail: wanwen@shu.edu.cn, jhao@shu.edu.cn

b School of Science, Shanghai University, China

c Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China

Abstract

A palladium(II)-catalyzed decarboxylative meta-selective C–H difluoromethylation of arenes has been developed from easily accessible difluoroacetic acids. Initial mechanistic studies disclosed that a reasonable migratory insertion is involved in this meta-C–H functionalization.

Graphical abstract: Pd(ii)-Catalyzed decarboxylative meta-C–H difluoromethylation

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Article information

DOI
https://doi.org/10.1039/C9CC00984A
Article type
Communication
Submitted
02 Feb 2019
Accepted
03 Mar 2019
First published
04 Mar 2019

Chem. Commun., 2019,55, 3927-3930

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Pd(II)-Catalyzed decarboxylative meta-C–H difluoromethylation

H. Zhao, G. Ma, X. Xie, Y. Wang, J. Hao and W. Wan, Chem. Commun., 2019, 55, 3927 DOI: 10.1039/C9CC00984A

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