Issue 27, 2019

Pd(ii)-Catalyzed decarboxylative meta-C–H difluoromethylation

Abstract

A palladium(II)-catalyzed decarboxylative meta-selective C–H difluoromethylation of arenes has been developed from easily accessible difluoroacetic acids. Initial mechanistic studies disclosed that a reasonable migratory insertion is involved in this meta-C–H functionalization.

Graphical abstract: Pd(ii)-Catalyzed decarboxylative meta-C–H difluoromethylation

Supplementary files

Article information

Article type
Communication
Submitted
02 Feb 2019
Accepted
03 Mar 2019
First published
04 Mar 2019

Chem. Commun., 2019,55, 3927-3930

Pd(II)-Catalyzed decarboxylative meta-C–H difluoromethylation

H. Zhao, G. Ma, X. Xie, Y. Wang, J. Hao and W. Wan, Chem. Commun., 2019, 55, 3927 DOI: 10.1039/C9CC00984A

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