We present a DNA-encoded chemical library, which allows dynamic selection followed by ligation of the encoding strands. As a chemical approach to mimic the genetic recombination process of adaptive immunity, the technology led to an enhanced enrichment factor and signal-to-noise ratio compared to static libraries.
F. V. Reddavide, M. Cui, W. Lin, N. Fu, S. Heiden, H. Andrade, M. Thompson and Y. Zhang, Chem. Commun., 2019, 55, 3753 DOI: 10.1039/C9CC01429B
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