Issue 34, 2019
From the journal:

Chemical Communications

Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery†

Keonwook Nam,‡a   Taehyung Kim,‡a   Young Min Kim,a   Kyungjik Yang,a   Deokyoung Choe, ORCID logo a   Lawrence B. Mensah,b   Ki Young Choi ORCID logo c  and  Young Hoon Roh ORCID logo *a  

* Corresponding authors

a Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea
E-mail: yr36@yonsei.ac.kr

b Department of Chemical Engineering and Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA

c Natural Product Informatics Research Center, Korea Institute of Science and Technology, 679 Saimdang-ro, Gangneung-si, Gangwon-do 25451, Republic of Korea

Abstract

We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.

Graphical abstract: Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

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Article information

DOI
https://doi.org/10.1039/C9CC01442J
Article type
Communication
Submitted
20 Feb 2019
Accepted
05 Mar 2019
First published
06 Mar 2019

Chem. Commun., 2019,55, 4905-4908

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Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

K. Nam, T. Kim, Y. M. Kim, K. Yang, D. Choe, L. B. Mensah, K. Y. Choi and Y. H. Roh, Chem. Commun., 2019, 55, 4905 DOI: 10.1039/C9CC01442J

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