Site-selective C(sp3)–H amination of thioamide with anthranils under Cp*CoIII catalysis

Abstract

Synthetically versatile anthranils as a bifunctional amino source have been employed for the first time to enable direct amination on unactivated C(sp³)–H bonds of thioamides under Cp*Co^III catalysis. The excellent site-selectivity on primary C(sp³)–H bonds is observed for a diverse array of thioamides with high functional group tolerance. Further applicability of the products is also highlighted through a series of interesting synthetic elaborations.