Issue 43, 2019
From the journal:

Chemical Communications

A DNA walker powered by endogenous enzymes for imaging uracil-DNA glycosylase activity in living cells†

Xiaowen Xu,a   Pingping Zhang,a   Ruiyuan Zhang,a   Nan Zhang*b  and  Wei Jiang ORCID logo *a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Shandong University, 250100 Jinan, P. R. China
E-mail: wjiang@sdu.edu.cn
Fax: +86 531 88564464
Tel: +86 531 88363888

b Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, 250012 Jinan, P. R. China
E-mail: zlkzn2016@126.com

Abstract

A DNA walker powered by endogenous enzymes is constructed. It performs automatic walking in living cells and can detect the uracil-DNA glycosylase activity in situ.

Graphical abstract: A DNA walker powered by endogenous enzymes for imaging uracil-DNA glycosylase activity in living cells

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Article information

DOI
https://doi.org/10.1039/C9CC01912J
Article type
Communication
Submitted
08 Mar 2019
Accepted
26 Apr 2019
First published
26 Apr 2019

Chem. Commun., 2019,55, 6026-6029

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A DNA walker powered by endogenous enzymes for imaging uracil-DNA glycosylase activity in living cells

X. Xu, P. Zhang, R. Zhang, N. Zhang and W. Jiang, Chem. Commun., 2019, 55, 6026 DOI: 10.1039/C9CC01912J

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