Issue 45, 2019
From the journal:

Chemical Communications

A dual-functional molecular strategy for in situ suppressing and visualizing of neuraminidase in aqueous solution using iridium(iii) complexes†

Chun Wu,‡a   Ke-Jia Wu,‡b   Jin-Biao Liu, ORCID logo ‡ac   Xiao-Ming Zhou,d   Chung-Hang Leung ORCID logo *b  and  Dik-Lung Ma ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Hong Kong Baptist University, Kowloon, Hong Kong, China
E-mail: edmondma@hkbu.edu.hk

b State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
E-mail: duncanleung@um.edu.mo

c School of Metallurgical and Chemical Engineering, Jiangxi University of Science and Technology, Ganzhou, China

d MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China

Abstract

We have designed for the first time a dual-functional luminescent probe and inhibitor of neuraminidase (NA), a key influenza target. The lead iridium(III) complex exhibited enhanced inhibition against NA compared to the FDA-approved antiviral drug, oseltamivir, and could detect NA even in the presence of an autofluorescent background.

Graphical abstract: A dual-functional molecular strategy for in situ suppressing and visualizing of neuraminidase in aqueous solution using iridium(iii) complexes

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Article information

DOI
https://doi.org/10.1039/C9CC02189B
Article type
Communication
Submitted
19 Mar 2019
Accepted
01 May 2019
First published
01 May 2019

Chem. Commun., 2019,55, 6353-6356

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A dual-functional molecular strategy for in situ suppressing and visualizing of neuraminidase in aqueous solution using iridium(III) complexes

C. Wu, K. Wu, J. Liu, X. Zhou, C. Leung and D. Ma, Chem. Commun., 2019, 55, 6353 DOI: 10.1039/C9CC02189B

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