pH-sensitive loaded retinal/indocyanine green micelles as an “all-in-one” theranostic agent for multi-modal imaging in vivo guided cellular senescence-photothermal synergistic therapy

Lipeng Zhu; Ping Li; Duyang Gao; Jie Liu; Yubin Liu; Chen Sun; Mengze Xu; Xin Chen; Zonghai Sheng; Ruibing Wang; Zhen Yuan; Lintao Cai; Yifan Ma; Qi Zhao

doi:10.1039/C9CC02567G

pH-sensitive loaded retinal/indocyanine green micelles as an “all-in-one” theranostic agent for multi-modal imaging in vivo guided cellular senescence-photothermal synergistic therapy†

Lipeng Zhu,‡^a Ping Li,‡^b Duyang Gao,^c Jie Liu,^a Yubin Liu,^a Chen Sun,^b Mengze Xu,^a Xin Chen,^b Zonghai Sheng,^c Ruibing Wang,^b Zhen Yuan,

^a Lintao Cai,

^c Yifan Ma*^c and Qi Zhao

*^a

Author affiliations

* Corresponding authors

^a Cancer Centre, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China
E-mail: qizhao@um.edu.mo

^b State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR 999078, China

^c Key Lab of Health Informatics of Chinese Academy of Sciences, Guangdong Key Laboratory of Nanomedicine, Shenzhen Institutes of Advanced Technology, Chinese Academy of Science, Shenzhen 518055, China
E-mail: mayifan@shhryz.com

Abstract

In this study, pH-sensitive loaded retinal/indocyanine green (ICG) micelles were developed to realize novel approaches for cellular senescence-photothermal synergistic therapy to treat cancer. The micelles could enable effective multi-modal imaging in vivo guided therapy and show anticancer activity in vitro and in vivo with satisfactory biosafety.

Chemical Communications

pH-sensitive loaded retinal/indocyanine green micelles as an “all-in-one” theranostic agent for multi-modal imaging in vivo guided cellular senescence-photothermal synergistic therapy†

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pH-sensitive loaded retinal/indocyanine green micelles as an “all-in-one” theranostic agent for multi-modal imaging in vivo guided cellular senescence-photothermal synergistic therapy

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