Issue 44, 2019
From the journal:

Chemical Communications

Triangeliphthalides A–D: bioactive phthalide trimers with new skeletons from Angelica sinensis and their production mechanism†

Jian Zou,‡ab   Guo-Dong Chen,‡a   Huan Zhao,c   Xiao-Xia Wang,a   Zai-Jun Zhang,d   Yi-Bo Qu,e   Rong-Rong He,a   Kwok-Fai So,d   Xin-Sheng Yao ORCID logo a  and  Hao Gao ORCID logo *a  

* Corresponding authors

a Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China
E-mail: tghao@jnu.edu.cn

b Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, People's Republic of China

c College of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, People's Republic of China

d Institute of New Drug Research, College of Pharmacy/Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University, Guangzhou 510632, People's Republic of China

e GMH Institute of Central Nervous System Regeneration, Guangdong Medical Key Laboratory of Brain Function and Diseases, Jinan University, Guangzhou 510632, People's Republic of China

Abstract

Triangeliphthalides A–D (1–4), four novel phthalide trimers with two new linkage styles, were isolated from Angelica sinensis, together with two related phthalide dimers (5–6). Their structures including absolute configurations were determined. The production mechanism of phthalide polymers was proposed, and their bioactivities were also evaluated.

Graphical abstract: Triangeliphthalides A–D: bioactive phthalide trimers with new skeletons from Angelica sinensis and their production mechanism

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Article information

DOI
https://doi.org/10.1039/C9CC02681A
Article type
Communication
Submitted
08 Apr 2019
Accepted
30 Apr 2019
First published
02 May 2019

Chem. Commun., 2019,55, 6221-6224

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Triangeliphthalides A–D: bioactive phthalide trimers with new skeletons from Angelica sinensis and their production mechanism

J. Zou, G. Chen, H. Zhao, X. Wang, Z. Zhang, Y. Qu, R. He, K. So, X. Yao and H. Gao, Chem. Commun., 2019, 55, 6221 DOI: 10.1039/C9CC02681A

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