Ring opening of epoxides with [18F]FeF species to produce [18F]fluorohydrin PET imaging agents†
Stefan
Verhoog, 
‡§a
Allen F.
Brooks,
§a
Wade P.
Winton,
a
Benjamin L.
Viglianti,
ab
Melanie S.
Sanford
*c
and
Peter J. H.
Scott
*a
‡§a
Allen F.
Brooks,
§a
Wade P.
Winton,
a
Benjamin L.
Viglianti,
ab
Melanie S.
Sanford
*c
and
Peter J. H.
Scott
*a
Abstract
A simple technique for the preparation of [18F]HF has been developed and applied to the generation of an [18F]FeF species for opening sterically hindered epoxides. This method has been successfully employed to prepare four drug-like molecules, including 5-[18F]fluoro-6-hydroxy-cholesterol, a potential adrenal/endocrine PET imaging agent. This easily automated one-pot procedure produces sterically hindered fluorohydrin PET imaging agents in good yields and high molar activities.
![Graphical abstract: Ring opening of epoxides with [18F]FeF species to produce [18F]fluorohydrin PET imaging agents](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C9CC02779C&imageInfo.ImageIdentifier.Year=2019)
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