Allylation of aldehydes by dual photoredox and nickel catalysis

Andrea Gualandi; Giacomo Rodeghiero; Adriana Faraone; Filippo Patuzzo; Marianna Marchini; Francesco Calogero; Rossana Perciaccante; Thomas Paul Jansen; Paola Ceroni; Pier Giorgio Cozzi

doi:10.1039/C9CC03344K

Allylation of aldehydes by dual photoredox and nickel catalysis†

Andrea Gualandi,

*^a Giacomo Rodeghiero,^ab Adriana Faraone,^a Filippo Patuzzo,^a Marianna Marchini,^a Francesco Calogero,^a Rossana Perciaccante,^b Thomas Paul Jansen,^b Paola Ceroni

*^a and Pier Giorgio Cozzi

*^a

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* Corresponding authors

^a Dipartimento di Chimica “G. Ciamician”, ALMA MATER STUDIORUM Università di Bologna, Via Selmi 2, 40126 Bologna, Italy
E-mail: andrea.gualandi10@unibo.it, paola.ceroni@unibo.it, piergiorgio.cozzi@unibo.it

^b Cyanagen Srl, Via Stradelli Guelfi 40/C, Bologna, Italy

Abstract

Here we report the application of dual nickel/photoredox catalysis to the allylation of aliphatic, aromatic and heteroaromatic aldehydes by using commercially available reagents. The process utilizes the combination of a Ni(II) complex, [Ru(bpy)₃]²⁺ as a photoredox catalyst, and allylacetate under blue LED irradiation, and allows the synthesis of a large variety of homoallylic alcohols.

Chemical Communications

Allylation of aldehydes by dual photoredox and nickel catalysis†

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Allylation of aldehydes by dual photoredox and nickel catalysis

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