Issue 51, 2019
From the journal:

Chemical Communications

Optimizing aromatic oligoamide foldamer side-chains for ribosomal translation initiation†

Christos Tsiamantas, ORCID logo ‡a   Sunbum Kwon, ORCID logo ‡bc   Céline Douat, ORCID logo bd   Ivan Huc ORCID logo *b  and  Hiroaki Suga ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo, Japan
E-mail: hsuga@chem.s.u-tokyo.ac.jp

b Department of Pharmacy and Center for Integrated Protein Science, Ludwig-Maximilians-Universität, Butenandtstraße 5-13, D-81377 München, Germany
E-mail: ivan.huc@lmu.de

c Department of Chemistry, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea

d CBMN (UMR5248), Univ. Bordeaux – CNRS – IPB., Institut Européen de Chimie et Biologie, 2 rue Escarpit, 33600 Pessac, France

Abstract

The tolerance of ribosomal peptide translation for helical aromatic oligoamide foldamers appended as initiators has been investigated. Small cationic foldamer side-chains were shown to expand the range of foldamer-peptide hybrids that can be produced by the ribosome to more rigid sequences.

Graphical abstract: Optimizing aromatic oligoamide foldamer side-chains for ribosomal translation initiation

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Article information

DOI
https://doi.org/10.1039/C9CC03547H
Article type
Communication
Submitted
08 May 2019
Accepted
27 May 2019
First published
30 May 2019

Chem. Commun., 2019,55, 7366-7369

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Optimizing aromatic oligoamide foldamer side-chains for ribosomal translation initiation

C. Tsiamantas, S. Kwon, C. Douat, I. Huc and H. Suga, Chem. Commun., 2019, 55, 7366 DOI: 10.1039/C9CC03547H

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