Issue 68, 2019
From the journal:

Chemical Communications

Quantification of CYFRA 21-1 and a CYFRA 21-1–anti-CYFRA 21-1 autoantibody immune complex for detection of early stage lung cancer†

Keum-Soo Song, ORCID logo ‡a   Satish Balasaheb Nimse, ORCID logo ‡a   Shrikant Dashrath Warkad, ORCID logo a   Ae-Chin Oh, ORCID logo b   Taisun Kim ORCID logo *a  and  Young Jun Hong ORCID logo *b  

* Corresponding authors

a Institute of Applied Chemistry and Department of Chemistry, Hallym University, Chuncheon, South Korea
E-mail: tskim@hallym.ac.kr

b Departments of Laboratory Medicine, Korea Cancer Center Hospital, Seoul, South Korea
E-mail: clinchem@kirams.re.kr

Abstract

Population-based screening of stage 0–I lung cancer is crucial to save lives. In this article, we describe the development of a method for the detection of a CYFRA 21-1-autoantibody complex and CYFRA 21-1 in plasma samples. The CIC/CYFRA 21-1 ratio allows the detection of stage I–IV lung cancer with 76.0% sensitivity and 87.5% specificity.

Graphical abstract: Quantification of CYFRA 21-1 and a CYFRA 21-1–anti-CYFRA 21-1 autoantibody immune complex for detection of early stage lung cancer

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Article information

DOI
https://doi.org/10.1039/C9CC03620B
Article type
Communication
Submitted
10 May 2019
Accepted
05 Jun 2019
First published
22 Jul 2019
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2019,55, 10060-10063

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Quantification of CYFRA 21-1 and a CYFRA 21-1–anti-CYFRA 21-1 autoantibody immune complex for detection of early stage lung cancer

K. Song, S. B. Nimse, S. D. Warkad, A. Oh, T. Kim and Y. J. Hong, Chem. Commun., 2019, 55, 10060 DOI: 10.1039/C9CC03620B

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