Issue 53, 2019

Nickel-catalyzed monofluoromethylation of (hetero)aryl bromides via reductive cross-coupling

Abstract

A mild and efficient nickel-catalyzed direct monofluoromethylation of (hetero)aryl bromides by reductive cross-coupling has been developed. This method exhibits good efficiency, wide functional-group compatibility, and suitability for aryl and heteroaryl bromides with abundant industrial raw material BrCH2F. This strategy provides an efficient way to synthesize monofluoromethylated molecules for drug discovery.

Graphical abstract: Nickel-catalyzed monofluoromethylation of (hetero)aryl bromides via reductive cross-coupling

Supplementary files

Article information

Article type
Communication
Submitted
15 May 2019
Accepted
06 Jun 2019
First published
07 Jun 2019

Chem. Commun., 2019,55, 7635-7638

Nickel-catalyzed monofluoromethylation of (hetero)aryl bromides via reductive cross-coupling

H. Yin, J. Sheng, K. Zhang, Z. Zhang, K. Bian and X. Wang, Chem. Commun., 2019, 55, 7635 DOI: 10.1039/C9CC03737C

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