A crystallographically characterised zinc(II)-capped foldamer can sense the enantiomeric excess of scalemic carboxylate solutions, including those produced by enantioselective organocatalysis, and can relay this input signal along the foldamer body to a remote glycinamide group, which then provides an NMR spectroscopic output.
N. Eccles, B. A. F. Le Bailly, F. della Sala, I. J. Vitórica-Yrezábal, J. Clayden and S. J. Webb, Chem. Commun., 2019, 55, 9331 DOI: 10.1039/C9CC03895G
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