A proof-of-principle for the application of hemi-indigo derivatives as RNA binders with photocontrollable fluorescence is presented. The photoswitch binds to the human immunodeficiency virus type 1 (HIV-1) RNA with a significant light-up effect. The fluorescence of the RNA-bound ligand can be reversibly switched ON and OFF by light without destroying the ligand–RNA associates.
D. V. Berdnikova, Chem. Commun., 2019, 55, 8402 DOI: 10.1039/C9CC04270A
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