Umpolung cross-coupling of polyfluoroarenes with hydrazones via activation of C–F bonds

Abstract

An umpolung strategy for the cross-coupling of polyfluoroarenes with various substituted hydrazones to construct C(sp²)–C(sp³) bonds is developed. In this strategy, the C–F bond of polyfluoroarenes is cleaved and coupled with moisture- and air-stable hydrazones under mild conditions with good to excellent yields. This method provides a useful tool for synthesizing polyfluorinated pharmaceuticals and functional materials.