Issue 67, 2019

Highly selective and wash-free visualization of resistant bacteria with a relebactam-derived fluorogenic probe

Abstract

Reported herein is a relebactam-derived fluorogenic reagent for covalent labeling of serine β-lactamases (SBLs), which are the major causes of bacterial resistance to β-lactam antibiotics. This highly selective imaging reagent generates over 300-fold stronger near-infrared fluorescence signals upon covalently bonding to SBLs, allowing wash-free visualization of live antimicrobial-resistant bacteria.

Graphical abstract: Highly selective and wash-free visualization of resistant bacteria with a relebactam-derived fluorogenic probe

Supplementary files

Article information

Article type
Communication
Submitted
13 Jun 2019
Accepted
12 Jul 2019
First published
22 Jul 2019

Chem. Commun., 2019,55, 9919-9922

Highly selective and wash-free visualization of resistant bacteria with a relebactam-derived fluorogenic probe

Y. Chen, M. Xu, W. Xu, H. Song, L. Hu, S. Xue, S. Zhang, X. Qian and H. Xie, Chem. Commun., 2019, 55, 9919 DOI: 10.1039/C9CC04533C

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