Issue 67, 2019
From the journal:

Chemical Communications

Highly selective and wash-free visualization of resistant bacteria with a relebactam-derived fluorogenic probe†

Yefeng Chen,‡a   Minqiu Xu,‡a   Weipan Xu,a   Heng Song,a   Liqiang Hu,a   Shuyuan Xue,a   Shuangzhan Zhang,a   Xiana Qiana  and  Hexin Xie ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
E-mail: xiehexin@ecust.edu.cn

Abstract

Reported herein is a relebactam-derived fluorogenic reagent for covalent labeling of serine β-lactamases (SBLs), which are the major causes of bacterial resistance to β-lactam antibiotics. This highly selective imaging reagent generates over 300-fold stronger near-infrared fluorescence signals upon covalently bonding to SBLs, allowing wash-free visualization of live antimicrobial-resistant bacteria.

Graphical abstract: Highly selective and wash-free visualization of resistant bacteria with a relebactam-derived fluorogenic probe

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Article information

DOI
https://doi.org/10.1039/C9CC04533C
Article type
Communication
Submitted
13 Jun 2019
Accepted
12 Jul 2019
First published
22 Jul 2019

Chem. Commun., 2019,55, 9919-9922

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Highly selective and wash-free visualization of resistant bacteria with a relebactam-derived fluorogenic probe

Y. Chen, M. Xu, W. Xu, H. Song, L. Hu, S. Xue, S. Zhang, X. Qian and H. Xie, Chem. Commun., 2019, 55, 9919 DOI: 10.1039/C9CC04533C

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