Issue 69, 2019
From the journal:

Chemical Communications

A tumor microenvironment model coupled with a mass spectrometry system to probe the metabolism of drug-loaded nanoparticles†

Ling Lin, ORCID logo *ab   Yajing Zheng,ac   Zengnan Wu, ORCID logo ac   Wei Zhangab  and  Jin-Ming Lin ORCID logo b  

* Corresponding authors

a CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, People's Republic of China
E-mail: linling@nanoctr.cn

b University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

c Beijing Key Laboratory of Microanalytical Methods and Instrumentation, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, People's Republic of China

Abstract

This study describes a novel integrated microfluidic platform with microvessel network channels which are connected to an electrospray ionization-mass spectrometer (ESI-MS), allowing real-time probing of nanoparticle (NP) drug delivery in vascular niche around tumors and understanding the drug delivery efficacy in a realistic tumor microenvironment.

Graphical abstract: A tumor microenvironment model coupled with a mass spectrometry system to probe the metabolism of drug-loaded nanoparticles

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Article information

DOI
https://doi.org/10.1039/C9CC04628C
Article type
Communication
Submitted
17 Jun 2019
Accepted
19 Jul 2019
First published
22 Jul 2019

Chem. Commun., 2019,55, 10218-10221

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A tumor microenvironment model coupled with a mass spectrometry system to probe the metabolism of drug-loaded nanoparticles

L. Lin, Y. Zheng, Z. Wu, W. Zhang and J. Lin, Chem. Commun., 2019, 55, 10218 DOI: 10.1039/C9CC04628C

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