A ratiometric fluorescent DNA nanoprobe for cerebral adenosine triphosphate assay

Zhichao Liu; Peicong Wu; Yaoyao Yin; Yang Tian

doi:10.1039/C9CC05046A

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A ratiometric fluorescent DNA nanoprobe for cerebral adenosine triphosphate assay†

Zhichao Liu,‡^a Peicong Wu,‡^a Yaoyao Yin^a and Yang Tian

*^a

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* Corresponding authors

^a Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Dongchuan Road 500, Shanghai 200241, P. R. China
E-mail: ytian@chem.ecnu.edu.cn

Abstract

A silver nanocluster-based ratiometric fluorescent nanosensor was developed for the determination of ATP in the cerebrospinal fluid of a mouse brain. Using this useful tool with good stability and high selectivity as well as a wide linear detection range, it was found that the ATP concentration in a mouse brain with Alzheimer's disease was 2300-fold higher than that in a normal one.

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Article information

DOI: https://doi.org/10.1039/C9CC05046A
Article type: Communication
Submitted: 02 Jul 2019
Accepted: 24 Jul 2019
First published: 25 Jul 2019

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Chem. Commun., 2019,55, 9955-9958

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A ratiometric fluorescent DNA nanoprobe for cerebral adenosine triphosphate assay

Z. Liu, P. Wu, Y. Yin and Y. Tian, Chem. Commun., 2019, 55, 9955 DOI: 10.1039/C9CC05046A

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Chemical Communications

A ratiometric fluorescent DNA nanoprobe for cerebral adenosine triphosphate assay†

Abstract

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A ratiometric fluorescent DNA nanoprobe for cerebral adenosine triphosphate assay

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