Issue 69, 2019
From the journal:

Chemical Communications

Mitochondria-targeted Ir@AuNRs as bifunctional therapeutic agents for hypoxia imaging and photothermal therapy†

Libing Ke,‡a   Cheng Zhang,‡a   Xinxing Liao,a   Kangqiang Qiu,a   Thomas W. Rees,a   Yu Chen, ORCID logo *a   Zizhuo Zhao,*b   Liangnian Jia  and  Hui Chao ORCID logo *ac  

* Corresponding authors

a MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China
E-mail: ceschh@mail.sysu.edu.cn, chenyu63@mail.sysu.edu.cn

b Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510275, P. R. China
E-mail: zhaozizh@mail.sysu.edu.cn

c MOE Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. China

Abstract

Ir(III) complex modified gold nanorods, Ir@AuNRs, were developed as mitochondria-targeted theranostic nanoagents. Their hypoxia imaging and photothermal therapeutic properties were demonstrated in vitro and in vivo.

Graphical abstract: Mitochondria-targeted Ir@AuNRs as bifunctional therapeutic agents for hypoxia imaging and photothermal therapy

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Article information

DOI
https://doi.org/10.1039/C9CC05610F
Article type
Communication
Submitted
19 Jul 2019
Accepted
05 Aug 2019
First published
05 Aug 2019

Chem. Commun., 2019,55, 10273-10276

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Mitochondria-targeted Ir@AuNRs as bifunctional therapeutic agents for hypoxia imaging and photothermal therapy

L. Ke, C. Zhang, X. Liao, K. Qiu, T. W. Rees, Y. Chen, Z. Zhao, L. Ji and H. Chao, Chem. Commun., 2019, 55, 10273 DOI: 10.1039/C9CC05610F

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