Issue 75, 2019
From the journal:

Chemical Communications

Phosphorylation dependent α-synuclein degradation monitored by in-cell NMR†

Wenwen Zheng,‡ab   Zeting Zhang,‡a   Yansheng Ye,‡a   Qiong Wu,a   Maili Liua  and  Conggang Li ORCID logo *a  

* Corresponding authors

a Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China
E-mail: conggangli@wipm.ac.cn
Fax: +86 27 87199291

b Graduate University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

Here we report the dephosphorylation and proteolysis of phosphorylated α-synuclein, a Parkinson's disease-related protein, in living cells in a time resolved manner using in-cell NMR.

Graphical abstract: Phosphorylation dependent α-synuclein degradation monitored by in-cell NMR

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Article information

DOI
https://doi.org/10.1039/C9CC05662A
Article type
Communication
Submitted
22 Jul 2019
Accepted
21 Aug 2019
First published
21 Aug 2019

Chem. Commun., 2019,55, 11215-11218

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Phosphorylation dependent α-synuclein degradation monitored by in-cell NMR

W. Zheng, Z. Zhang, Y. Ye, Q. Wu, M. Liu and C. Li, Chem. Commun., 2019, 55, 11215 DOI: 10.1039/C9CC05662A

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