Bifunctional supramolecular prodrug vesicles constructed from a camptothecin derivative with a water-soluble pillar[5]arene for cancer diagnosis and therapy

Guangping Sun; Zhimei He; Min Hao; Zuqiang Xu; Xiao-Yu Hu; Jun-Jie Zhu; Leyong Wang

doi:10.1039/C9CC05859A

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Bifunctional supramolecular prodrug vesicles constructed from a camptothecin derivative with a water-soluble pillar[5]arene for cancer diagnosis and therapy†

Guangping Sun,^a Zhimei He,

^b Min Hao,^a Zuqiang Xu,^a Xiao-Yu Hu,

*^ac Jun-Jie Zhu

*^b and Leyong Wang

*^ad

Author affiliations

* Corresponding authors

^a Key Laboratory of Mesoscopic Chemistry of MOE, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China
E-mail: lywang@nju.edu.cn

^b State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
E-mail: jjzhu@nju.edu.cn

^c College of Material Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, China
E-mail: huxy@nuaa.edu.cn

^d School of Petrochemical Engineering, Changzhou University, Changzhou, China

Abstract

Bifunctional supramolecular prodrug vesicles have been successfully constructed based on the complexation between a glutathione (GSH)-responsive prodrug guest molecule (DNS-CPT) and a water-soluble pillar[5]arene (WP5) for cancer diagnosis and therapy. Under the microenvironment of cancer cells with high GSH concentration, 7-ethyl-10-hydroxycamptothecin (SN-38) with strong yellow fluorescence can be efficiently released from the prodrug DNS-CPT for drug location and cancer therapy.

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Article information

DOI: https://doi.org/10.1039/C9CC05859A
Article type: Communication
Submitted: 28 Jul 2019
Accepted: 14 Aug 2019
First published: 15 Aug 2019

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Chem. Commun., 2019,55, 10892-10895

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Bifunctional supramolecular prodrug vesicles constructed from a camptothecin derivative with a water-soluble pillar[5]arene for cancer diagnosis and therapy

G. Sun, Z. He, M. Hao, Z. Xu, X. Hu, J. Zhu and L. Wang, Chem. Commun., 2019, 55, 10892 DOI: 10.1039/C9CC05859A

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Chemical Communications

Bifunctional supramolecular prodrug vesicles constructed from a camptothecin derivative with a water-soluble pillar[5]arene for cancer diagnosis and therapy†

Abstract

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Bifunctional supramolecular prodrug vesicles constructed from a camptothecin derivative with a water-soluble pillar[5]arene for cancer diagnosis and therapy

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