Issue 73, 2019

Coordination promiscuity guarantees metal substrate selection in transmembrane primary-active Zn2+ pumps

Abstract

Metal selectivity in P1B-type ATPase pumps appears to be determined by amino acid motifs on their transmembrane helices. We reveal the principles governing substrate promiscuity towards first-, second- and third-row transition metals in a transmembrane Zn2+/Cd2+/Hg2+/Pb2+ P-type ATPase (ZntA), by dissecting its coordination chemistry. Atomic resolution characterization in detergent micelles and lipid bilayers reveals a “plastic” transmembrane metal-binding site that selects substrates by unique and diverse, yet defined, coordination geometries and ligand–metal distances.

Graphical abstract: Coordination promiscuity guarantees metal substrate selection in transmembrane primary-active Zn2+ pumps

Supplementary files

Article information

Article type
Communication
Submitted
30 Jul 2019
Accepted
08 Aug 2019
First published
12 Aug 2019

Chem. Commun., 2019,55, 10844-10847

Coordination promiscuity guarantees metal substrate selection in transmembrane primary-active Zn2+ pumps

M. J. Gallenito, G. W. Irvine, L. Zhang and G. Meloni, Chem. Commun., 2019, 55, 10844 DOI: 10.1039/C9CC05936A

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