BANGO SEA XLOC/HMBC–H2OBC: complete heteronuclear correlation within minutes from one NMR pulse sequence

Abstract

Novel NMR experiments, BANGO SEA XLOC–H2OBC or BANGO HMBC–H2OBC, can deliver complete heteronuclear correlation maps on a time scale of minutes for small molecules. By way of example, it is demonstrated that all intra- and inter-residue ¹H and ¹³C correlations and assignments of a trisaccharide are obtained in 20 or 5 minutes of instrument time without or with 25% NUS, respectively.