Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators

Abstract

Multivalent mannosides with inherent macrophage recognition abilities, built on β-cyclodextrin, RAFT cyclopeptide or peptide dendrimer cores, trigger selective inhibition of lysosomal β-glucocerebrosidase or α-mannosidase depending on valency and topology, offering new opportunities in multitargeted drug design.