Mitochondrial heat shock protein-guided photodynamic therapy

Ajesh P. Thomas; An-Jung Lee; L. Palanikumar; Batakrishna Jana; Kibeom Kim; Sangpil Kim; Haewon Ok; Jihoon Seol; Dongseok Kim; Byoung Heon Kang; Ja-Hyoung Ryu

doi:10.1039/C9CC06411G

Mitochondrial heat shock protein-guided photodynamic therapy†

Ajesh P. Thomas,‡^a An-Jung Lee,‡^b L. Palanikumar,^a Batakrishna Jana,^a Kibeom Kim,^a Sangpil Kim,^a Haewon Ok,^a Jihoon Seol,^a Dongseok Kim,^a Byoung Heon Kang*^b and Ja-Hyoung Ryu

*^a

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^a Department of Chemistry, School of Natural Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan-44919, South Korea

^b Department of Biological Sciences, School of Natural Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan-44919, South Korea
E-mail: jhryu@unist.ac.kr, kangbh@unist.ac.kr

Abstract

Mitochondria targeting sensitizers are continuing to gain importance in photodynamic therapy (PDT). Members of the 90 kDa heat shock protein (Hsp90) family, including TRAP1 (Hsp75), are overexpressed in cancer cells and help to control the antiapoptotic protein activity. The present work introduces an Hsp90 inhibitor-mitochondria targeting indocyanine dye conjugate (IR-PU) for high PDT efficacy.

Chemical Communications

Mitochondrial heat shock protein-guided photodynamic therapy†

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