Target-triggered, self-powered DNAzyme–MnO2 nanosystem: towards imaging microRNAs in living cells

Mei-Rong Cui; Xiang-Ling Li; Jing-Juan Xu; Hong-Yuan Chen

doi:10.1039/C9CC06623C

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Target-triggered, self-powered DNAzyme–MnO₂ nanosystem: towards imaging microRNAs in living cells†

Mei-Rong Cui,^a Xiang-Ling Li,*^a Jing-Juan Xu

*^a and Hong-Yuan Chen^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
E-mail: xlli@nju.edu.cn, xujj@nju.edu.cn

Abstract

A target-triggered, self-powered strategy for in situ monitoring of intracellular microRNAs was fabricated via a versatile DNAzyme–MnO₂ nanosystem, which integrates delivery, quenching, target recognition, self-supply of cofactors and signal amplification all in one.

Download options Please wait...

Supplementary files

Supplementary information PDF (750K)

Article information

DOI: https://doi.org/10.1039/C9CC06623C
Article type: Communication
Submitted: 26 Aug 2019
Accepted: 09 Oct 2019
First published: 10 Oct 2019

Download Citation

Chem. Commun., 2019,55, 13366-13369

Permissions

Request permissions

Target-triggered, self-powered DNAzyme–MnO₂ nanosystem: towards imaging microRNAs in living cells

M. Cui, X. Li, J. Xu and H. Chen, Chem. Commun., 2019, 55, 13366 DOI: 10.1039/C9CC06623C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications