Light-activated drug release from prodrug nanoassemblies by structure destruction

Yang Li; Shujuan Wang; Yulan Huang; Yuwen Chen; Wenbi Wu; Yu Liu; Jing Zhang; Yue Feng; Xian Jiang; Maling Gou

doi:10.1039/C9CC06673J

Light-activated drug release from prodrug nanoassemblies by structure destruction†

Yang Li,‡^a Shujuan Wang,‡^a Yulan Huang,^a Yuwen Chen,^a Wenbi Wu,^a Yu Liu,^a Jing Zhang,^b Yue Feng,^c Xian Jiang^d and Maling Gou

*^a

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* Corresponding authors

^a State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China
E-mail: goumaling@scu.edu.cn

^b Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, China

^c The School of Clinical Medicine, Southwest Medical University, Luzhou, Sichuan Province 646000, China

^d Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China

Abstract

We report here a novel light-triggered nanosystem based on co-assembling nanoaggregates (NAs) of lipophilic photosensitizers and lipophilic prodrugs containing multiple thioethers. Upon laser irradiation, the oxidization of the multiple thioethers by photosensitizer-generated singlet oxygen could rapidly destroy the NA structure, resulting in faster drug release than those containing a single thioether.

Chemical Communications

Light-activated drug release from prodrug nanoassemblies by structure destruction†

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