Issue 87, 2019
From the journal:

Chemical Communications

Azo-based near-infrared fluorescent theranostic probe for tracking hypoxia-activated cancer chemotherapy in vivo†

Ning Ding,a   Zhao Li, ORCID logo *a   Xinwei Tian,a   Jiahang Zhang,a   Kaili Guob  and  Pan Wang ORCID logo b  

* Corresponding authors

a Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, China
E-mail: lizhao0309@snnu.edu.cn

b Ministry of Education Key Laboratory of Medicinal Resources and Natural, Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an 710062, China

Abstract

A novel azo-based near-infrared fluorescent theranostic probe was synthesized, which is selectively activated under hypoxic conditions, resulting in the release of an active anticancer drug and a near-infrared fluorophore turn-on. Notably, the probe has been applied successfully to real-time visualization of drug delivery in 4T1, HepG2 cells, and mice.

Graphical abstract: Azo-based near-infrared fluorescent theranostic probe for tracking hypoxia-activated cancer chemotherapy in vivo

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Article information

DOI
https://doi.org/10.1039/C9CC06727B
Article type
Communication
Submitted
29 Aug 2019
Accepted
02 Oct 2019
First published
02 Oct 2019

Chem. Commun., 2019,55, 13172-13175

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Azo-based near-infrared fluorescent theranostic probe for tracking hypoxia-activated cancer chemotherapy in vivo

N. Ding, Z. Li, X. Tian, J. Zhang, K. Guo and P. Wang, Chem. Commun., 2019, 55, 13172 DOI: 10.1039/C9CC06727B

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