Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.
W. Y. Kim, M. Won, A. Salimi, A. Sharma, J. H. Lim, S. Kwon, J. Jeon, J. Y. Lee and J. S. Kim, Chem. Commun., 2019, 55, 13267 DOI: 10.1039/C9CC07009E
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