Tailored ultra-small Prussian blue-based nanoparticles for MRI imaging and combined photothermal/photoacoustic theranostics

Abstract

Ultrasmall sub-10 nm nanoparticles of Prussian blue analogues incorporating Gd^III ions at their periphery revealed longitudinal relaxivities above 40 mM⁻¹ s⁻¹ per Gd^III regardless of the nature of the core and the polymer coating. Large T₁-weighted contrast enhancements were achieved in addition to a highly efficient photothermal effect and in vivo photoacoustic imaging in tumors.