Cp*CoIII-catalyzed formal [4+2] cycloaddition of benzamides to afford quinazolinone derivatives

Jingshu Yang; Xiao Hu; Zijie Liu; Xueyuan Li; Yi Dong; Gang Liu

doi:10.1039/C9CC07173C

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Cp*Co^III-catalyzed formal [4+2] cycloaddition of benzamides to afford quinazolinone derivatives†

Jingshu Yang,‡^a Xiao Hu,‡^a Zijie Liu,^bc Xueyuan Li,^a Yi Dong

*^bc and Gang Liu

*^a

Author affiliations

* Corresponding authors

^a School of Pharmaceutical Sciences, Tsinghua University, Haidian District, Beijing 100084, China
E-mail: gangliu27@tsinghua.edu.cn

^b State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
E-mail: dongyi@imm.ac.cn

^c Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

Abstract

A Cp*Co^III-catalyzed arene C–H bond amidation/annulation of benzamides was developed to afford quinazolinone derivatives in one-pot with high yields and broad substrate scope. This method could be applied to the synthesis of quinazolinone drugs and late-stage modification of natural products.

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Article information

DOI: https://doi.org/10.1039/C9CC07173C
Article type: Communication
Submitted: 13 Sep 2019
Accepted: 22 Oct 2019
First published: 22 Oct 2019

Download Citation

Chem. Commun., 2019,55, 13840-13843

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Cp*Co^III-catalyzed formal [4+2] cycloaddition of benzamides to afford quinazolinone derivatives

J. Yang, X. Hu, Z. Liu, X. Li, Y. Dong and G. Liu, Chem. Commun., 2019, 55, 13840 DOI: 10.1039/C9CC07173C

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