Palladium(ii)-catalyzed oxidative C(sp3)–P bond formation via C(sp3)–H bond activation

Abstract

Disclosed herein is a Pd(II)-catalyzed C(sp³)–H/P–H oxidative cross-coupling reaction between 8-methylquinolines with H-phosphonates or diarylphosphine oxides via chelation-assisted C(sp³)–H bond activation. The protocol exhibits a relatively broad functional-group tolerance and exclusive chemo- and regioselectivity. Furthermore, detailed mechanistic studies support the proposed reaction pathway.