Construction of seven- and eight-membered carbocycles by Lewis acid catalyzed C(sp3)–H bond functionalization

Abstract

We achieved a concise construction of seven- and eight-membered carbocycles via Lewis acid catalyzed C(sp³)–H bond functionalization. In these reactions, a quite rare [1,6 (or 7)]-hydride shift/cyclization process proceeded smoothly to afford seven- and eight-membered carbocycles with good chemical yields starting from substrates with high conformational freedom.