Issue 18, 2019
From the journal:

CrystEngComm

Co-crystal polymorphic control by nanodroplet and electrical confinement†

L. M. Padrela, ORCID logo a   B. Castro-Dominguez,b   A. Ziaee,a   B. Long,a   K. M. Ryan, ORCID logo a   G. Walkera  and  E. J. O'Reilly ORCID logo *a  

* Corresponding authors

a Synthesis and Solid State Pharmaceutical Centre (SSPC), Bernal Institute University of Limerick Limerick, Limerick, Ireland
E-mail: Emmet.OReilly@ul.ie

b Chemical Engineering Department, University of Bath, Claverton Down, BA2 7AY Bath, UK

Abstract

The polymorphic control of the co-crystal carbamazepine–saccharin (CBZ–SAC) metastable form II was achieved by nano-droplet confinement in tandem with droplet surface charging induced by electrospraying the precursor solution. Polymorphic exclusivity is independent of solvent selection. CBZ–SAC co-crystals obtained by electrospraying are compared with supercritical CO2 nano spray-drying, conventional spray-drying and solvent evaporation methods.

Graphical abstract: Co-crystal polymorphic control by nanodroplet and electrical confinement

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Article information

DOI
https://doi.org/10.1039/C9CE00060G
Article type
Communication
Submitted
11 Jan 2019
Accepted
17 Apr 2019
First published
18 Apr 2019

CrystEngComm, 2019,21, 2845-2848

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Co-crystal polymorphic control by nanodroplet and electrical confinement

L. M. Padrela, B. Castro-Dominguez, A. Ziaee, B. Long, K. M. Ryan, G. Walker and E. J. O'Reilly, CrystEngComm, 2019, 21, 2845 DOI: 10.1039/C9CE00060G

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