Issue 25, 2019

Self-suppression from metabolin with a precursor in pathology crystallization of gout

Abstract

Hyperuricemia is typically defined as occurring above the saturation point of monosodium urate monohydrate (MSUM), which occurs at serum urate levels >6.8 mg dL−1. Xanthine(X), a precursor molecule of uric acid, was found to inhibit the growth of MSUM crystals through incorporating into the surface of bulk crystal of MSUM. This approach can provide us with a new perspective that will help our understanding of the heterogeneity of gout in hyperuricemics and the processes of crystal formation and growth of MSUM.

Graphical abstract: Self-suppression from metabolin with a precursor in pathology crystallization of gout

Supplementary files

Article information

Article type
Communication
Submitted
15 Feb 2019
Accepted
04 Jun 2019
First published
04 Jun 2019

CrystEngComm, 2019,21, 3774-3778

Self-suppression from metabolin with a precursor in pathology crystallization of gout

Y. Liu, J. Jing, C. Ou, X. Zhang, S. Jiang, R. Chen and T. Fu, CrystEngComm, 2019, 21, 3774 DOI: 10.1039/C9CE00214F

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