Issue 12, 2019

DNA interaction of ruthenium(ii) complexes with imidazo[4,5-f][1,10]phenanthroline derivatives

Abstract

In this paper, the DNA interaction properties of four Ru(II) polypyridyl complexes, [Ru(bpy)2(pip)]2+ (1), bpy = 2,2′-bipyridine, pip = 2-phenyl-imidazo[4,5-f][1,10]phenanthroline, [Ru(bpy)2(nip)]2+ (2), nip = 2-naphthyl-imidazo[4,5-f][1,10]phenanthroline, [Ru(bpy)2(aip)]2+ (3), aip = 2-(9-anthryl)-imidazo[4,5-f][1,10]phenanthroline and [Ru(bpy)2(pyip)]2+ (4), pyip = 2-(1-pyrenyl)-imidazo[4,5-f][1,10]phenanthroline, were investigated by spectral titration. The intensity increases in the MLCT band of the complexes and the decrease in absorption due to the DNA secondary structure was attributed to DNA condensation by these complexes. The DNA condensing behavior of these complexes was investigated in more detail by gel electrophoresis (GAR), dynamic light scattering (DLS), zeta potential, atomic force microscopy (AFM), and transmission electron microscopy (TEM). The results suggest that the concentration of the complex plays a critical role in its DNA intercalating and DNA condensing behavior. Meanwhile, the aryl units in the ligands of complex 1–4 also have a large effect on their interactions with DNA.

Graphical abstract: DNA interaction of ruthenium(ii) complexes with imidazo[4,5-f][1,10]phenanthroline derivatives

Supplementary files

Article information

Article type
Paper
Submitted
31 Jan 2019
Accepted
25 Feb 2019
First published
26 Feb 2019

Dalton Trans., 2019,48, 3914-3921

DNA interaction of ruthenium(II) complexes with imidazo[4,5-f][1,10]phenanthroline derivatives

B. Yu, T. W. Rees, J. Liang, C. Jin, Y. Chen, L. Ji and H. Chao, Dalton Trans., 2019, 48, 3914 DOI: 10.1039/C9DT00454H

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