Issue 14, 2019

Manganese(ii)-catalysed dehydrogenative annulation involving C–C bond formation: highly regioselective synthesis of quinolines

Abstract

An inexpensive nontoxic manganese(II)-catalysed dehydrogenative annulation was developed for C–C bond formation. The reaction showed high selectivity and efficiency across a broad substrate scope. Remarkably simple conditions and the ability to conduct gram-scale synthesis underscore this method's utility. To demonstrate the potential of this approach, we tested the drug effects of compound 3n, which showed activity for blocking vascular development. The results of this study will be important for the treatment of eye diseases and tumors caused by vascular proliferation.

Graphical abstract: Manganese(ii)-catalysed dehydrogenative annulation involving C–C bond formation: highly regioselective synthesis of quinolines

Supplementary files

Article information

Article type
Communication
Submitted
13 Feb 2019
Accepted
04 Mar 2019
First published
05 Mar 2019

Dalton Trans., 2019,48, 4474-4478

Manganese(II)-catalysed dehydrogenative annulation involving C–C bond formation: highly regioselective synthesis of quinolines

C. Wang, J. Yang, X. Meng, Y. Sun, X. Man, J. Li and F. Sun, Dalton Trans., 2019, 48, 4474 DOI: 10.1039/C9DT00647H

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