Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment

Abstract

We present a facile approach of a switchable polymer–gold nanoparticle, which programmatically co-delivers genes and chemical drugs (gene-chem). Between the delivery pathway and specific diseased cells the nanoparticle is switchable and allows for enhanced computed tomography (CT) imaging and synergistic neuronal recovery. The delivery system with precise conversion will serve as a powerful gene-chem co-delivery platform to enable accurate brain disease therapy.