Issue 1, 2019

Thiol-free oligonucleotide surface modification of gold nanoparticles for nanostructure assembly

Abstract

Gold nanoparticles (AuNPs) decorated with thiol-modified DNA (HS-DNA) strands are an extensively studied, easily adjustable, and highly controllable material for constructing 3D nanostructures with various shapes and functions. However, few reproducible and robust methods involving DNA templates as a key reagent are available for obtaining 3D nanoparticle assemblies. It is still challenging to strictly control the number and location of DNA strands on the AuNP surface. Here, we introduce an efficient approach for the surface modification of AuNPs using unmodified DNA oligonucleotides by building DNA cages that trap the nanoparticles. This enables us to vary the process of nanostructure assembly and create anisotropic nanoparticles that are necessary for directed structure construction. This developed method simplifies the production process in comparison with conventional HS-DNA modification protocols and helps to precisely control the density and position of functional DNA strands designed for further hybridization with other AuNP conjugates.

Graphical abstract: Thiol-free oligonucleotide surface modification of gold nanoparticles for nanostructure assembly

Supplementary files

Article information

Article type
Paper
Submitted
13 Aug 2018
Accepted
19 Sep 2018
First published
20 Sep 2018
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2019,1, 430-435

Thiol-free oligonucleotide surface modification of gold nanoparticles for nanostructure assembly

A. O. Maslova and I. M. Hsing, Nanoscale Adv., 2019, 1, 430 DOI: 10.1039/C8NA00148K

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